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News and updates about Segue Therapeutics

New Publication in Molecular Carcinogenesis journal

Jared Snider

The paper titled Zinc finger E-box binding homeobox-1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ Exchanger-1 (NHE1) by Dykes et. al. has been accepted for publication by the journal Molecular Carcinogenesis. This paper concludes that lysosome trafficking in cells that have undergone epithelial-to-mesenchymal transition plays a major role in the ability of these tumor cells to invade leading to metastasis. This information further supports the company’s premise that targeting lysosome trafficking is a promising therapeutic approach to slow the progression of invasive cancers.